https://hdl.handle.net/20.500.14353/117 2026-05-07T07:27:19Z https://hdl.handle.net/20.500.14353/121 Prevalence of developmental delay among confirmed newborn screening test positive hypothyroid infants in Region VI (2006-2009). Faunillan, Carmina Jemema; Beluso, Heziel; Morales, Jenny Lyn; Matapaja, Reman John; Salcedo, Dibie Jane; David, James David; Villareal, Ma. Victoria BACKGROUND: Untreated Congenital hypothyroidism (CH) could lead to significant neurologic deficits, growth retardation and developmental delay. OBJECTIVE: The study aimed to determine the prevalence of developmental delay among patients in Region VI confirmed by the Newborn Screening Center Visayas (NBSC-V) to have CH. METHODS: This cross-sectional study was conducted in Iloilo City, Guimars, Capiz, Aklan, Bacolod City, Silay City, and Negros Occidental. Eighteen patients with CH confirmed by NBSVC-V from 2006-2009 were assessed. Thirty-six children with negative TSH screening test served as negative controls. Denver Developmental Screening Test was used to assess the personal-social, fine motor function, language and gross motor development. Neurodevelopmental assessment as either "normal" or "suspect" was the main outcome measure. RESULTS: Among the 116,567 patients screened by the Newborn Screening Center-Visayas from 2006-2009, there were 30 patients from Region VI with confirmed positive test for hypothyroidism. Of the 30 patients, 18 were assessed. Only 12 received appropriate treatment. Eleven were "normal" while 7 were "suspect" for developmental delay. Developmental delay among patients who received appropriate treatment (p=0.047). All patients who tested negative for CH were "normal". Among patients who received appropriate treatment, the percentage with "normal" development was comparable with the negative control(p=0.059). Developmental delay was significantly greater with CH without appropriate treatment compared to those in the negative control (p<0.0001). CONCLUSION: The prevalence of developmental delay among patients in Region VI confirmed by NBSC-V to have congenital hypothyroidism is 39%. KEYWORDS: developmental delay, congenital hypothyroidism, newborn screening, denver developmental screening test 2011-01-01T00:00:00Z https://hdl.handle.net/20.500.14353/122 Anesthetic activity of Tubli (Derris elliptica ) root extracts at varying concentrations and model of administration on male albino mice. Abella, Raye Angeli; Aldeguer, Patricia Joy; Cruz, Karen Jo; Macalala, Scarlet Erngil; Mampao, Jessa Monalee; Odjinar, Leonard; Rovillos, Kliendio; Salem, Freya Angela; Saliendr, Angelo Antoni; Tagaytay, Theo Genesis Background: there is need to explore the medicinal potential local plant species in the country. Tubli, an agricultural weed, has long been hypothesized to have anesthetic properties as observed in years of folk hunting and fishing practices in different regions in the country, and similarly among others countries which use root extract of the plant in immobilizing the target prey. Objective: This study aimed to determine the anesthetic potential of Tubli (DErris elliptica) root extract at specific concentrations and mode of administration. Methods: The study was conducted at the West Visayas State University College of Medicine Laboratory from April to May 200. Included were 360 three-month old albino mice., with 10 replicates for each type of administration at varying concentrations. D. elliptica root extract concentrations (0%, 10!%, 12% , 14%, 16%, 18%, 20%, and 22%) were administered via intramuscular (IM) injection and subcutaneous (SC) injection. Specific changes in behavior and activity of mice specimens upon treatment were observed and monitored. The optimum anesthetic activity of D. elliptica root extract, at different concentrations and varying modes of administration was determined using the Pain Test for analgesia and the Run Test for extent of paralysis. Changes test specimen behavior and activity were also monitored through Ethogram Test at 30-60 minute observation periods. Results: Runa and Pain Test results showed optimum anesthetic activity at 18% concentration via IM injections and at 20% concentration via SC injections. Significant differences were achieved between the different extract concentration tested. There was no significant difference between the two modes of administration performed. The anesthetic effect of D. elliptica remained localized. The duration of mice activity was greatly limited by the extent of paralysis on the tested limb. Other body activities remained intact implying localization of anesthetic effect. Conclusion: Tubli has potential medical importance because of its anesthetic properties at specific concentration and mode of administration. Keywords: Tubli, Derris Elliptic, Anesthetic, Paralysis, Analgesia 2011-01-01T00:00:00Z https://hdl.handle.net/20.500.14353/129 Larvicidal effect of varying concentrations of adelfa (Nerium oleander) leaf aqueous infusion on Aedes aegypti Herrera, Joseph; Madalag, Falwell Dan; Sorolla, Louvelle Thess; Cruz, Runica; Togonon, Johann Christine; Bellosillo, Illoza Joy; Hubag, Angelie Rose; Pialago, Edrik Luke; Sabellina, Sweet Madeen; Ledesma, Khamille Background: The current use of synthetic insecticides to control mosquito borne diseases such as Dengue Hemorrhagic Fever has created harmful effects on the environment. Hence, the search for biodegradable and less toxic insecticides from plant sources is beneficial. Objective: This study aimed to determined the larvicidal effect of varying concentrations of Adelfa (Nerium oleander) leaf infusion on Aedes aegypti larvae. Specifically, this was conducted to determined the LC50 and LC90 of Adelfa infusion. Methods: The experimental method of investigation was utilized in this study. The study was conducted in Jaro, Iloilo City. Third instar A. aegypti larvae were used as subjects. The A. aegypti larvae were exposed to four different concentrations (25%, 50%, 75% and 100% ) of Adelfa (N. oleander) leaf infusion. Malathion served as positive control. Tap water was used as negative control. The larvicidal effect of Adelfa was based on the percentage mortality of A. aegypti larvae after 24 hours of exposure and the lethal dose of the leaf infusion. Results: After 24 hours of exposure, a high mortality of A. aegypti was observed after exposure to 50%, 75% and 100% concentration of N. oleander leaf infusion. Analysis showed that there was a significant difference between the mean scores of the control group and the means scores of the treated group. Increase in concentration correspondent to increase in mortality of A. aegypti. It needed 42.33% concentration N. oleander to kill half of the population of A. aegypti larvae. Conclusion: Adelfa (N. oleander) leaf aqueous infusion has a concentration dependent larvicidal effect against A. aegypti . The LC50 and LC90 of N. oleander are 42.33% and 77.85%, respectively. Keywords: Larvicidal, Nerium oleander, Aedes aegypti, lethal concentration 2011-01-01T00:00:00Z