Multi-country study on the prevalence and clinical features of peripheral arterial disease in Asian type 2 diabetes patients at high risk of atherosclerosis
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Date
2007-04-01Author
MeSH term
Atherosclerosis![MeSH MeSH](/themes/Mirage2/images/MeSH-logo.jpg)
Asian People
![MeSH MeSH](/themes/Mirage2/images/MeSH-logo.jpg)
Diabetes Mellitus, Type 2
![MeSH MeSH](/themes/Mirage2/images/MeSH-logo.jpg)
Glycated Hemoglobin
![MeSH MeSH](/themes/Mirage2/images/MeSH-logo.jpg)
Hypertension
![MeSH MeSH](/themes/Mirage2/images/MeSH-logo.jpg)
Multicenter Studies as Topic
![MeSH MeSH](/themes/Mirage2/images/MeSH-logo.jpg)
Multivariate Analysis
![MeSH MeSH](/themes/Mirage2/images/MeSH-logo.jpg)
Prevalence
![MeSH MeSH](/themes/Mirage2/images/MeSH-logo.jpg)
Risk Factors
![MeSH MeSH](/themes/Mirage2/images/MeSH-logo.jpg)
Peripheral Vascular Diseases
![MeSH MeSH](/themes/Mirage2/images/MeSH-logo.jpg)
Triglycerides
![MeSH MeSH](/themes/Mirage2/images/MeSH-logo.jpg)
Peripheral Arterial Disease
![MeSH MeSH](/themes/Mirage2/images/MeSH-logo.jpg)
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Abstract
Objective:
PAD-SEARCH was the first international study to investigate the prevalence of peripheral arterial disease (PAD) in Asian type 2 diabetic patients and to demonstrate the relationships between putative risk factors and PAD.
Subjects and methods:
In total 6625 type 2 diabetic patients aged 50 and older were enrolled and determined ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) in Korea, China, Taiwan, Hong Kong, Indonesia, Thailand and the Philippines.
Results:
Mean patient age was 63.7 ± 8.2 years and mean duration of diabetes was 10.3 ± 8.0 years. One thousand one hundred and seventy-two (17.7%) subjects were diagnosed as PAD by ABI (≤0.9). PAD subjects had a significantly longer duration of diabetes, hypertension, higher HbA1c, and a significantly lower mean BMI than non-PAD subjects. In terms of lipid profiles, triglyceride was the only significant variable. Notably, mean ABI and baPWV in females were significantly poorer than age matched males in subjects with a normal ABI. However, mean ABI and baPWV in males were significantly poorer than in age matched females in subjects with PAD.
Conclusions:
These findings suggest that PAD is a common complication in Asian type 2 diabetic patients. Therefore, PAD screening and treatment should be emphasized for Asian diabetic patients with high risk factors.
Recommended Citation
Rhee, S. Y., Guan, H., Liu, Z.-M., Cheng, S. W. K., Waspadji, S., Palmes, P., ... & Kim, Y. S. (2007). Multi-country study on the prevalence and clinical features of peripheral arterial disease in Asian type 2 diabetes patients at high risk of atherosclerosis.Type
ArticleISSN
0168-8227; 1872-8227Keywords
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