Depression in X-linked dystonia-parkinsonism: A case-control study

Abstract

X-linked dystonia-parkinsonism (XDP), also known as lubag, was originally described as endemic to Panay, Philippines [ [1] ]. XDP demonstrates a primary and progressive neuronal degeneration of the striatum and is characterized by an adult-onset movement disorder that manifests as severe and progressive dystonia with a high frequency of generalization, followed by the onset of a parkinsonian state in the later years of life [ 1 , 2 ]. Suicide incidence has been reported to account for 9% of the mortality in patients with XDP [ [1] ]. Despite the high suicide risk, only a few case reports refer to mood disorders in patients with XDP. The purpose of this study was to determine the prevalence of depressive symptoms among patients with XDP.